Hi and welcome!
I don’t know if Jupyter Notebook can. Of course, JupyterHub can but that’s almost a separate product. So much so that if you have JupyterHub already, you kind of don’t want Jupyter + OnDemand integration - JupyterHub just has a lot more to offer and we don’t integrate with it directly.
That said - JupyterLab/Notebook through OnDemand are for interactive jobs. I.e., jobs you’re actively interacting with. We often tell customers to run these programs in batch jobs if they require a long time to run (more than ~6 hours or so). Seems like that’d be the same guidance we’d give our own customers if they asked this question - instead of getting an interactive job with multiple machines, submit the work as a batch job that you don’t actively interact with.